Gene information
Official symbol BDKRB2
Official full name bradykinin receptor B2
Gene type protein-coding gene
Chromosome14q32.2
Alias symbolBK-2
Gene familyBradykinin receptors
Resources
Entrez Gene 624
HGNC HGNC:1030
Ensembl ENSG00000168398
Vega OTTHUMG00000171408
UCSC uc001yfg.3
GO terms: 45 records
GO Description Category LogP Number of genes Detail
GO:0001653 peptide receptor activity GO Molecular Functions -6.43798881 12 More
GO:0001664 G protein-coupled receptor binding GO Molecular Functions -22.7408810 35 More
GO:0001933 negative regulation of protein phosphorylation GO Biological Processes -19.8214973 59 More
GO:0002020 protease binding GO Molecular Functions -28.8254555 31 More
GO:0003012 muscle system process GO Biological Processes -27.3938503 63 More
GO:0003013 circulatory system process GO Biological Processes -65.2875605 130 More
GO:0003018 vascular process in circulatory system GO Biological Processes -47.1670528 52 More
GO:0006869 lipid transport GO Biological Processes -16.6388990 29 More
GO:0006936 muscle contraction GO Biological Processes -17.3443769 27 More
GO:0006939 smooth muscle contraction GO Biological Processes -6.47455620 13 More
GO:0006954 inflammatory response GO Biological Processes -86.5569367 100 More
GO:0007167 enzyme-linked receptor protein signaling pathway GO Biological Processes -26.8285253 93 More
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway GO Biological Processes -16.7048742 60 More
GO:0007204 positive regulation of cytosolic calcium ion concentration GO Biological Processes -15.6883547 39 More
GO:0008015 blood circulation GO Biological Processes -65.7270163 119 More
GO:0008528 G protein-coupled peptide receptor activity GO Molecular Functions -6.62401664 12 More
GO:0009651 response to salt stress GO Biological Processes -4.88843929 5 More
GO:0010563 negative regulation of phosphorus metabolic process GO Biological Processes -21.7837721 71 More
GO:0010876 lipid localization GO Biological Processes -20.1994935 34 More
GO:0015849 organic acid transport GO Biological Processes -6.14345140 15 More
GO:0015908 fatty acid transport GO Biological Processes -7.46702847 10 More
GO:0015909 long-chain fatty acid transport GO Biological Processes -7.56395612 9 More
GO:0016788 hydrolase activity, acting on ester bonds GO Molecular Functions -4.57583420 56 More
GO:0019229 regulation of vasoconstriction GO Biological Processes -25.9471687 22 More
GO:0031400 negative regulation of protein modification process GO Biological Processes -17.0986645 70 More
GO:0033135 regulation of peptidyl-serine phosphorylation GO Biological Processes -8.68560410 14 More
GO:0035150 regulation of tube size GO Biological Processes -44.5138102 41 More
GO:0035296 regulation of tube diameter GO Biological Processes -44.6572858 41 More
GO:0042310 vasoconstriction GO Biological Processes -9.70418585 13 More
GO:0042311 vasodilation GO Biological Processes -18.7593927 16 More
GO:0042326 negative regulation of phosphorylation GO Biological Processes -20.6187298 64 More
GO:0042578 phosphoric ester hydrolase activity GO Molecular Functions -4.79997475 34 More
GO:0043114 regulation of vascular permeability GO Biological Processes -8.20071376 14 More
GO:0044057 regulation of system process GO Biological Processes -61.6610386 136 More
GO:0045936 negative regulation of phosphate metabolic process GO Biological Processes -21.8424865 71 More
GO:0046903 secretion GO Biological Processes -18.5147167 70 More
GO:0046982 protein heterodimerization activity GO Molecular Functions -2.81006698 12 More
GO:0080135 regulation of cellular response to stress GO Biological Processes -19.0128542 89 More
GO:0090066 regulation of anatomical structure size GO Biological Processes -32.7608623 52 More
GO:0097746 blood vessel diameter maintenance GO Biological Processes -44.6572858 41 More
GO:1901796 regulation of signal transduction by p53 class mediator GO Biological Processes -2.39461048 11 More
GO:1902532 negative regulation of intracellular signal transduction GO Biological Processes -29.4927428 92 More
GO:1903522 regulation of blood circulation GO Biological Processes -44.9821911 79 More
GO:2001233 regulation of apoptotic signaling pathway GO Biological Processes -35.8481080 51 More
GO:2001234 negative regulation of apoptotic signaling pathway GO Biological Processes -32.1748782 40 More
KEGG pathways: 6 records
KEGG Description Category LogP Number of genes Detail
hsa04020 Calcium signaling pathway KEGG Pathway -10.4415222 36 More
hsa04022 cGMP-PKG signaling pathway KEGG Pathway -9.74555098 16 More
hsa04080 Neuroactive ligand-receptor interaction KEGG Pathway -22.6219922 65 More
hsa04610 Complement and coagulation cascades KEGG Pathway -50.1154932 39 More
hsa05142 Chagas disease KEGG Pathway -21.3868632 23 More
hsa05200 Pathways in cancer KEGG Pathway -30.6393212 92 More
Drug-Gene interaction
view
Related drugs: 12 records
Drug name Interaction type Source PMID View
anatibant antagonist TdgClinicalTrialChemblInteractionsTTD 10596852 view
atorvastatin PharmGKB view
bradykinin agonist TTD view
deltibant TTD view
enalapril PharmGKB 2270662012522467 view
fasitibant chloride antagonist ChemblInteractions view
icatibant antagonist TdgClinicalTrialTENDTTD 1451403311752352 view
icatibant acetate antagonist ChemblInteractions view
imidapril PharmGKB 12522467 view
labradimil agonist ChemblInteractions 111606521116065111286321 view
lisinopril PharmGKB 12522467 view
volanesorsen sodium NCI 10775071 view
Related studies: 3 records
Molecular factor Omics type Application Objective MI type Reference
NM_000623.4:c.-58T>C genomics hypertension[prognosis (bad)] acute myocardial infarction Aoki S et al. Jpn Circ J. 2001
B2 bradykinin receptor proteomics heart failure[prognosis (bad)] ST elevation myocardial infarction Fu C et al. Dis Markers. 2019
B2 bradykinin receptor proteomics coronary revascularization[prognosis (bad)] ST elevation myocardial infarction Fu C et al. Dis Markers. 2019
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